Section: New Results

RNA kinetics using non-redundant sampling

RNA kinetics is arguably the next frontier in RNA 2D bioinformatics. In particular, computational methods for studying the kinetics of RNA beyond 150nts are hindered by the combinatorial explosion of the conformation space. In an effort to circumvent such an effect, we have proposed a sampling approach that explicitly target local minima of the energy function. Our sampling algorithm, jointly proposed with H. Touzet (Bonsai, Inria Lille & CrisTaL, Univ. Lille I) and accepted for a presentation at the ISMB/ECCB'17 conference in Prague [15], uses non-redundant sampling principles to avoid an excessive concentration of samples within low local minima.