Section: Highlights of the Year

Highlights of the Year

- Launch of the Graduate's School Digital Public Health (PI: R Thiebaut) including the Master of Public Health Data Sciences

- Launch of the IMI project EBOVAC3 in which R Thiebaut is leader of the workpackage "Modelling". Concomitantly, we have obtained the first results of the modelling of the response to the Ebola vaccine developped with Janssen company (submitted to Journal of Virology).

- A new step of the work on IL-7 therapy in HIV infected patients has been achieved through the optimization of the administration of the injections. Approaches from statistical modelling and control theory demonstrated the feasibility of reducing the administration of IL-7 while improving its efficacy.

- The project on the automatic recognition of cell populations through high dimensional cytometry data has reached a successful stage with two important publications. It is now applied to clinical trial datasets available through the Vaccine Research Insitute.

- The data warehouse system developed through the EHVA European consortium is settled in its version 1.0 and will be used for the storage of all SISTM datasets as well as to implement the software developed for the analysis of immunological data.

- Funding of the EDCTP Prevac-UP in which M Prague is leader of the workpackage "System vaccinology approach". The aim is to develop an integrative analysis of all immunological data generated to understand antibodies response to Ebola vaccination.

- Funding of the Franco-Sino INSERM project on NiPAH virus in which M Prague is leader of the workpackage "Modeling, biostatistics and bioinformatics". The aim of this workpackage is to conduct state of the art quantitative analyses of effects of therapeutic and vaccine strategies, as well as providing a framework to bridge results from in vitro to in vivo and between different animal models.

- Marta Avalos undertook a 6-month research visit to Data61 (CSIRO, Canberra, Australia) in 2017. This collaboration has reached a successful stage with one publication in NeurIPS 2018.