Section: Application Domains

Experimental research in oncology

We use mathematical modeling as a tool to assist biological cancer research in testing mechanistic hypotheses and pharmacological research. More specifically, our applications include:

• Theoretical biology of the metastatic process: dynamics of a population of tumors in mutual interactions, dormancy, pre-metastatic and metastatic niche, quantification of metastatic potential and differential effects of anti-angiogenic therapies on primary tumor and metastases,

• Rational and personalized dosing and scheduling of anti-cancer drugs in monotherapy or in combination,

• Mathematical modeling of intra-tumor drug transport to optimize the design of nanoparticules